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|On Demand Webinar|| Hydrogenation and High Pressure Reaction Monitoring |
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understanding about key reaction parameters that enabled successful hydrogenation.
|On Demand Webinar|| Monitoring Cell Count, Size and Shape in Fermentation Processes |
Fermentation process monitoring including E. Coli, mammalian cells, plant cells and filamentous organisms are discussed in this webinar
|On Demand Webinar|| Top Five Ways To Improve Laboratory Crystallization |
This webinar discusses five ways to identify ideal crystallization conditions in the laboratory. Key stages in the process development lifecycle where laboratory crystallization has been improved are included.
|On Demand Webinar|| In Situ Monitoring of Chemical Reactions - Recent Advances in Organic Chemistry Part 3 |
In situ Fourier Transform Infrared (FTIR) provides real-time monitoring of chemical reactions and is suitable for a wide range of chemistries and applications. This presentation demonstrates how ReactIR™ supports the fundamental understanding of organic chemistry and enables chemical engineering research.
|On Demand Webinar|| Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a PAT Tool |
The use of real-time in situ mid-infared (mid-IR) analytics as a Process Analytical Technology (PAT) tool early in process development has become widespread particularly in the pharmaceutical industry in order to run information rich experiments which results in shorter project timelines. Not only does this result in meeting Quality by Design (QbD) objectives, but it also results in the ability to move processes to the manufacturing environment faster.
|On Demand Webinar|| Roller Compaction Process Optimization Using At-Line Particle Characterization |
One goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution. However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.
|On Demand Webinar|| Simplify Process Characterization by Combining Thermal Data with In Situ IR Spectroscopy |
The capabilities and advantages of monitoring kinetics using online infrared (IR) techniques in combination with precisely controlled synthesis workstations or reaction calorimeters is presented using different reactions.
|On Demand Webinar|| Application of Quantitative Analysis to Predict Absolute Concentration Information in Real-time |
Relative concentration is sufficient for reaction progression information such as initiation, intermediate formation and endpoint. However, the ability to predict absolute concentration in real-time is sometimes desired or essential, especially during production monitoring, and for monitoring and controlling continuous processes. Part IV discusses the application of quantitative analysis using real-time in situ FTIR focusing on strategies that produce the best quantitative results for the desired outcome. Software tools for quantitative method evaluation will also be covered. This is Part IV of the webinar series - Introduction to Real-time In Situ FTIR for Rapid Reaction Progression Determination and Reaction Characterization.
|On Demand Webinar|| Innovative Approaches for the Synthesis and Purification of Peptide Libraries |
Peptide libraries are widely investigated and routinely screened for their drug-like properties. Synthesis using resins or solid supports is a favorite route for researchers performing peptide synthesis. However, synthesis and subsequent purification are major bottlenecks encountered during synthesis of peptide libraries. This webinar examines challenges related to the synthesis of peptide libraries and will discuss various applications including the synthesis of cyclic peptides employing a unique safety-catch linker, which enables the production of diverse libraries for biological screening.
|On Demand Webinar|| iC Quant™: What are Factors and How Are They Used in Quantitative and Discriminate Analysis? |
|On Demand Webinar|| Use of PAT and Laboratory Automation from the Pharmaceutical & Chemical Industries - New Developments |
Intergration of process analyzers and process automation together with the use of multivariate tools for design, data acquisition and analysis is critical and listed in Food and Drug Administration (FDA) guidance of Process Analytical Technology (PAT). Their use helps conduct information-rich experiments that respond to the need for increased process development throughput, downstream consistency and reliability.
|On Demand Webinar|| Introduction to Reaction Analysis Using Real-Time In Situ FTIR |
This webinar introduces the use of Fourier Transform Infrared Spectroscopy (FTIR) for reaction analysis and monitoring, and includes a comparison to other well known spectroscopic techniques. The method of measurement and probe and sensor options available will be discussed as well as best practices on how to collect high quality data that will facilitate easy interpretation.
|On Demand Webinar|| Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes |
The quantitative use of in situ ATR-FTIR for real time supersaturation assessment has been extremely well defined within the literature. However, these now well structured and understood methodologies have yet to be incorporated into the standard pharmaceutical crystallization development due to time and calibration/statistical analysis experience. In this webinar, a method will be presented which facilitates the calibration free use of in situ ATR-FTIR spectra for the production and control of qualitative supersaturation trajectories.
|On Demand Webinar|| In Situ Flow Technology to Continuous Processing - Part I |
The ReactIR™ flow cell is presented as a convenient inline analytical tool for continuous flow chemistry processing. The flow cell, operated with ATR technology, is attached inline using standard Omnifit® connections. With the established iC IR 4.0 software the consumption of reagents and formation of products can be monitored in real-time, allowing for rapid optimization. Unstable reactive intermediates can also be observed in situ, giving mechanistic insight to complex transformations.
|On Demand Webinar|| Role of Process Analytical Technology (PAT) in Green Chemistry and Green Engineering |
Process Analytical Technology (PAT) case studies are presented on how the principles of Green Chemistry and Green Engineering have been leveraged in chemical reactions and crystallization design.
|On Demand Webinar|| Advances in Metal-Catalyzed Chemical Transformations |
Advances in metal-catalyzed chemical transformations and other organic chemistry are reviewed during this online seminar. This is Part 4 of the Recent Advances in Organic Chemistry Webinar Series.
|On Demand Webinar|| Conversion Prediction of an Enzymatic Esterification |
This online seminar focuses on the implementation of FTIR-based online analytics in the production of fatty acid esters. A new process using Novozym 435 as a catalyst in a highly viscous solvent free environment was developed and tested at pilot scale. The optimization of operation parameters and process control analytics using FTIR for this process will be discussed.
|On Demand Webinar|| Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions |
During this free webinar, Donna Blackmond will discuss how the Reaction Progress Kinetic Analysis (RPKA) methodology simplifies kinetic studies of organic reactions.
|On Demand Webinar|| Chemical Synthesis and Optimization Supported by Design of Experiments (DoE) - Lonza Peptide |
Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide.
|On Demand Webinar|| Faster, Better Organic Chemistry Through Use of Real-Time In Situ FTIR Optimized for the Organic Chemist |
This webinar discusses how organic chemists combine in situ FTIR reaction monitoring tools and will present several case studies to illustrate the value they bring to the organic chemist working in early product and process development.
|On Demand Webinar|| Tracking Inline Cell Count and Dimension to Ensure Targeted Cell Culture Productivity |
|On Demand Webinar|| Synthetic Chemistry - Increase Productivity and Reduce R&D Spending |
The challenges of implementing new concepts in the organic synthesis lab and the acceptance by chemists are discussed. Case studies highlight the successful implementation of the new synthetic chemistry technologies to reduce R&D spending and increase productivity.
|On Demand Webinar|| Safe Scale-up of Chemical Processes at Chilworth |
This presentation discusses how to ensure the safety of a process, when they should be performed, and how the outcomes of the tasks should be integrated to maximize the benefit. The safety of a process is not purely the domain of chemical engineers. Chemists dictate the intrinsic hazards of the process.
|On Demand Webinar|| Improving the Crystallization of Highly Energetic Materials with Inline Particle Measurement |
|On Demand Webinar|| Rapid Optimization and Control of Solids Flocculation |
Flocculation is a common separation technique in the biotechnology, mining, petroleum, and pulp and paper industries. Flocculation is a process where fine suspended particles aggregate to form larger flocs which improve solids separation from the liquid phase. Performance of flocculating agents such as polymers and chemicals depends on the incoming particle size distribution, solids concentration, mixing efficiency, additive type and dosage. Flocculation effectiveness influences downstream separation, settling, flotation, and purification